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FDA Commissioner Urges DEA to Classify 7-OH Ingredient Used in E-Cigarettes as a Schedule I Controlled Substance

Jul.30.2025
FDA Commissioner Urges DEA to Classify 7-OH Ingredient Used in E-Cigarettes as a Schedule I Controlled Substance
FDA Commissioner Robert Califf urged the DEA to classify 7-OH, an opioid-like compound found in vapes, drinks, and gummies, as a Schedule I substance. The FDA plans national warnings for doctors and tighter control of high concentrations.

Key points:

 

·FDA recommends: FDA Commissioner Marty Makary announced that 7-hydroxymitragynine (7-OH) will be classified as a controlled substance due to its opioid-like properties. 

 

·Widespread availability: 7-OH can be found in e-cigarette stores, beverages, and children's gummies. 

 

·Regulatory measures: FDA recommends that 7-hydroxymitragynine above a certain concentration threshold be classified as a Schedule I controlled substance. 

 

·Public education: FDA has issued a report and warned healthcare providers, emphasizing the risks of abuse associated with 7-OH.

 

 

【2Firsts News Flash】On July 30th, according to Reuters, Marty Makary, director of the FDA, suggested that 7-hydroxymitragynine (7-OH) be classified as a controlled substance due to its opiate-like properties.

 

He stated at a press conference held at the Department of Health and Human Services in Washington D.C. that many products containing 7-OH are sold in e-cigarette stores, and this compound is also present in beverages and children's gummy candies.

 

The FDA's letter to the DEA will recommend classifying 7-OH above a certain concentration threshold as a Schedule I controlled substance.

 

The FDA stated that the abuse potential of 7-OH is increasingly being scrutinized due to its ability to bind to opioid receptors.

 

"It is sold in e-cigarette shops, tobacco shops, convenience stores, and gas stations across the United States," said Macari.

 

The FDA is in the process of releasing a report and sending warning letters to every doctor in America. Markari stated that the FDA will continue its efforts to educate the public.

 

References:
[1] FDA recommends 7-OH compound found in vapes be controlled
Also Read:
[1] U.S. Fourth Circuit Court Rules North Carolina Can Ban Sale of FDA-Unapproved E-Cigarette Products
[2] U.S. FDA to Review Philip Morris International’s IQOS Risk Modification Renewal Application in October

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